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In this lecture from This is Why, Dr. Busti will break down pioglitazone and the thiazolidinediones (TZDs) so you can confidently explain the mechanism, clinical use, side effects, and key contraindications for type 2 diabetes (T2DM).
You’ll learn how to:
- TZDs (pioglitazone): where they fit in type 2 diabetes (T2DM) therapy
- Mechanism of action: PPAR-γ agonist → increased insulin sensitivity (muscle/adipose) and improved glucose utilization
- Expected impact on A1C reduction and how long these drugs take to show benefit
- Practical comparisons: pioglitazone vs rosiglitazone
Side effects & safety (high yield)
- Weight gain and edema / fluid retention
- Heart failure risk (when to avoid TZDs)
- Fracture risk with TZDs
Drugs covered for SEO / review
- Pioglitazone (primary focus)
- Thiazolidinediones / TZDs (drug class)
- Rosiglitazone (comparison)
Chapter Table of Contents
00:00 - Introduction to TZDs
01:27 - Agents
01:52 - Indications & Uses
02:37 - Net Benefit
03:20 - Pharmacology
04:33 - Clinical Knowledge
14:31 - Summary
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#pioglitazone #thiazolidinediones #tzd #type2diabetes #busti
Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
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