This episode of This Is Why with Dr. Busti dives deep into the pharmacology of thiazide diuretics, one of the most impactful and enduring drug classes in cardiovascular medicine. Dr. Busti unpacks pharmacology 101: the mechanism of action, pharmacokinetics, clinical uses, and side effects of agents like hydrochlorothiazide, chlorthalidone, indapamide, and metolazone — connecting each concept to the “why” behind their clinical application. Listeners will gain clarity on how these drugs fit into hypertension management, how renal physiology drives their effects, and what to monitor for safe, effective patient care.

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The goals = Pharmacology made easy & pharmacology made relevant!

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Chapter Table of Contents

00:00:00 Introduction: Why Thiazide Diuretics Still Matter
00:03:13 Key Drugs in the Class: Hydrochlorothiazide, chlorthalidone, indapamide, & metolazone
00:07:06 Clinical Uses and Indications of Thiazide Diuretics
00:08:53 Mechanism of Action of Thiazide Diuretics Made Easy
00:12:58 How Thiazide Diuretics Work in the Nephron
00:37:26 Pharmacokinetics and Dosing Insights
00:43:51 Common Side Effects and Risks
00:52:00 Monitoring and Patient Counseling
00:59:00 Key Takeaways and Closing Thoughts

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#thiazidediuretics #diureticspharmacology #pharmacologymadeeasy #diuretics #usmlepharmacology #naplex #nclex #nursingpharmacology

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Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.