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Understand the GLP-1 receptor agonists—and why agents like semaglutide (Ozempic/Wegovy/Rybelsus), liraglutide, dulaglutide, and exenatide have become one of the most talked-about type 2 diabetes medications in modern practice. In this lecture from This is Why, Dr. Busti will break GLP-1s down in a clear, clinically relevant way so you can confidently explain how they work, when to use them, and what to watch for clinically when managing patients with type 2 diabetes and/or obesity.
You’ll learn how to:
- Mechanism of action: incretin mimetic effects (GLP-1) and what that means for glucose control
- Therapeutic use: where GLP-1 agonists fit in type 2 diabetes (T2DM) treatment strategies
- Key agents: semaglutide, plus comparisons to liraglutide, dulaglutide, and exenatide
- Benefits & counseling pearls: weight effects, dosing basics, and practical patient education
- Adverse effects & precautions: the high-yield safety points clinicians get tested on (and seen in clinical practice)
Chapters
00:00 GLP-1 Receptor Agonists (Anti-Diabetic Drugs) | What You’ll Learn
00:57 How This Pharmacology Review Works (Mechanisms → Effects → Side Effects)
01:57 GLP-1 Drug List: Exenatide, Liraglutide, Semaglutide, Dulaglutide + More
02:54 Indications & Common Uses: Type 2 Diabetes, Obesity, CV Risk, MASH
04:16 Choosing the Right Product: Formulations, Dosing, Insurance Realities
08:16 Net Benefits: Why GLP-1s Are “Game-Changers” in T2D & Weight Loss
09:23 Glucose-Dependent Insulin Secretion: Preserving Beta-Cell Function
12:46 Core Mechanism: Insulin ↑, Glucagon ↓, Satiety ↑, Gastric Emptying ↓
14:33 GI Side Effects & “Frozen Bowel” Risk: Why Titration Matters
16:27 PK/PD & Counseling: Half-Life, Dose Escalation, Avoiding Overdosing
18:33 Drug Absorption & Interactions: Delayed Gastric Emptying Considerations
19:15 Place in Therapy: When GLP-1s Are First-Line (Even Beyond Metformin)
21:48 Comorbidities: CKD, Obesity, Heart Failure Context + When to Avoid
31:05 Dosing Pearl: Oral Semaglutide (How to Take It Correctly)
34:57 Warnings & Monitoring: Thyroid Risk (MTC/MEN2), Pancreatitis, Gallbladder, Labs + Wrap-Up
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#glp1receptoragonist #semaglutide #type2diabetes #diabetesmedications #busti
Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
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