In this lecture from This is Why, Dr. Busti will break down Heparin (UFH) and Low-Molecular-Weight Heparins (LMWHs), such as enoxaparin (Lovenox) and dalteparin (Fragmin), with a clear, clinically relevant approach. If you’re studying anticoagulation or need a fast refresher on anticoagulants, this video is for you.

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In this lesson, you’ll learn:
- Heparin mechanism of action (UFH vs LMWH) + how they work in the clotting cascade
- Monitoring & labs: aPTT/PTT for UFH, anti–Factor Xa concepts for LMWH
- Dosing/administration pearls (IV vs SQ, onset/offset, bridging basics)
- Adverse effects & safety: bleeding, HIT (heparin-induced thrombocytopenia), contraindications
- Clinical comparisons: heparin vs enoxaparin, when each is commonly used

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The goal = make medical education easy and clinically relevant.

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Chapter Table of Contents
00:00:00 Heparins Explained: UFH vs LMWH Anticoagulants Overview
00:02:37 Heparin Drugs: UFH, Enoxaparin, Dalteparin, Fondaparinux
00:04:02 When to Use Heparins: DVT PE and ACS STEMI PCI
00:05:24 Why Choose Heparins: Net Benefit vs Other Anticoagulants
00:06:18 UFH Drip vs LMWH Injections: Practical Differences
00:08:18 Molecular Weight Matters: UFH vs LMWH vs Fondaparinux
00:10:04 UFH Is Unpredictable: Interpatient Variability and Monitoring
00:13:08 LMWH Is Predictable: Less Monitoring and Easier Dosing
00:14:14 Heparin-Induced Thrombocytopenia: What It Is and Why It Happens
00:16:33 LMWH Dosing Is Not Interchangeable: Anti-Xa Units Explained
00:19:49 Anti-Thrombin Requirement: Why Heparins Are Indirect Anticoagulants
00:20:45 Coagulation Cascade: Factor Xa to Thrombin
00:24:06 Why LMWH Inhibits Xa More Than IIa
00:27:14 Fondaparinux: Pure Factor Xa Inhibitor and Lowest HIT Risk
00:31:13 Dosing in Obesity: Over 150 kg and Anti-Xa Monitoring
00:34:50 Monitoring Heparin: aPTT Goals and ACT in PCI
00:38:05 HIT Diagnosis: Type 1 vs Type 2 and the 4T Score
00:46:04 Bleeding and Reversal: Protamine Sulfate for Heparins

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#UnfractionatedHeparin #LowMolecularWeightHeparin #Enoxaparin #Anticoagulation #drbusti

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Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.