To view this video, please enable marketing cookies from Cookie Preferences in the footer.
Tirzepatide (Mounjaro/Zepbound)—the dual incretin GIP/GLP-1 agonist—is a beneficial treatment of type 2 diabetes and/or obesity. In this lecture from This is Why, Dr. Busti will break down how tirzepatide works (MOA), why combining GIP + GLP-1 improves A1C reduction and supports weight loss, and where it fits in the treatment of type 2 diabetes. You’ll also get the high-yield points you need for exams and the bedside: tirzepatide dosing basics, common adverse effects, contraindications/precautions, and practical tips for patient counseling (nausea, GI effects, injection technique, and expectations).
You’ll learn how to:
- Tirzepatide overview: Mounjaro vs Zepbound
- GIP/GLP-1 agonist mechanism (dual incretin)
- Clinical use in type 2 diabetes
- A1C lowering + weight loss effects
- Adverse effects, warnings, and counseling pearls
The goal = make medical education easy and clinically relevant.
Chapter Table of Contents
00:00 GIP–GLP-1 Agonists Explained: Tirzepatide Overview (Diabetes & Obesity)
01:23 How This Review Is Structured: Agents, Uses, Mechanisms & Pearls
02:05 The Only Agent: Tirzepatide (Why It’s Separate From GLP-1s)
03:02 Formulations & Indications: Diabetes vs Chronic Weight Management
04:08 Net Benefits: Sustained A1C Reduction Without Beta-Cell Burnout
05:59 Weekly Injection vs Oral Therapy: Pros, Cons & Adherence
06:34 Incretin Pharmacology: GLP-1 vs GIP vs DPP-4 Inhibitors
07:54 Mechanism of Action: Insulin ↑, Glucagon ↓, Gastric Emptying ↓
09:26 Dual GIP + GLP-1 Effects: Why Weight Loss Is More Pronounced
10:48 Drug Absorption & PK: Gastric Emptying, Protein Binding, Half-Life
11:29 Place in Therapy: Where Tirzepatide Fits in Type 2 Diabetes
13:26 Secretagogues vs Non-Secretagogues: Why This Class Is Preferred
16:03 Comorbidities: When to Use (Obesity, CKD, ASCVD, HF)
17:49 When to Avoid: Gastroparesis, Pancreatitis, MEN2/MTC
23:10 Dosing, Titration & Safety: Avoiding GI Toxicity + Final Takeaways
If this helped you, please like, subscribe to our YouTube Channel, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.
Don’t forget to turn on notifications on YouTube so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!
#tirzepatide #mounjaro #gipglp1 #type2diabetes #busti
Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
More than just access—it’s where understanding deepens.
Create a free account or log in to gain access to this content!
Related Topics
