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Master Aspirin (ASA) fast with this Antiplatelet Pharmacology Made Easy & Relevant lecture. In this lecture from This is Why, Dr. Busti will make sure you learn how acetylsalicylic acid works as an antiplatelet drug, including COX-1 inhibition, decreased thromboxane A2 (TXA2), and reduced platelet aggregation—plus the key clinical takeaways for MI prevention, stroke prevention, and secondary prevention.
You’ll learn how to:
- Aspirin mechanism of action (COX inhibitor → ↓ TXA2 → ↓ platelet aggregation)
- Why aspirin is different from other NSAIDs in antiplatelet therapy
- High-yield uses in cardiovascular pharmacology (MI/stroke prevention)
- Side effects, contraindications, and safety pearls you need for exams
The goal = make medical education easy and clinically relevant.
Chapter Table of Contents
00:00 Aspirin Overview: Why This Antiplatelet Still Matters
02:11 Aspirin vs Salicylic Acid: Prodrug Concept and Absorption
04:30 Aspirin Indications: Acute vs Chronic Uses Explained
06:18 Primary vs Secondary Prevention: Where Aspirin Truly Helps
08:34 Net Benefit and Evidence: The ISIS-2 Trial Explained
11:44 Aspirin Mechanism of Action: COX Inhibition and Prostaglandins
14:00 COX-1 vs COX-2: Why Aspirin Works on Platelets
17:05 Irreversible Platelet Inhibition: Duration and Surgical Timing
22:36 Aspirin Dosing: Acute Loading vs Chronic Low-Dose Therapy
24:53 Clinical Pearls: Stroke, PCI, Kawasaki Disease, Preeclampsia
30:24 Contraindications and Adverse Effects: GI Bleeding, Asthma, Interactions
34:28 Toxicity and Special Populations: Salicylates, Reye Syndrome, Pregnancy
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Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
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