In this This Is Why with Dr. Busti pharmacology review, Dr. Busti explains the clinical science behind thyroid drug therapy (or thyroid hormone pharmacology) — one of the most commonly prescribed yet misunderstood treatments in medicine. Drawing from decades of experience as a nurse, pharmacist, and physician, Dr. Busti unpacks the mechanism of action, feedback regulation, pharmacokinetics, monitoring, and clinical pitfalls of drugs like levothyroxine (T4), liothyronine (T3), and desiccated thyroid. Learn why small dose changes can have big effects, how pregnancy and protein binding alter therapy, and how to manage patients safely in both outpatient and inpatient settings.

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The goals = Pharmacology Made Easy & Pharmacology Made Relevant

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Chapter Table of Contents

00:00 Introduction to Thyroid Drug Therapy
00:40 Why Thyroid Drug Therapy Matters Clinically & Therapeutically
02:43 Understanding T3 vs T4: Potency, Function & Clinical Roles
03:47 Indications: Hypothyroidism, Hashimoto’s, and Special Populations
04:39 Mechanism of Action: Nuclear Receptors & Gene Expression
04:54 Monitoring the Thyroid Axis: TSH, T4, and Target Ranges
13:30 Pharmacodynamic Effects: Half-Life, Steady State & Absorption Challenges
18:08 Pharmacokinetic Considerations: Dosing and Therapeutic Impacts
29:11 Practical Dosing Strategies: Timing, Consistency & Formulation Issues
30:22 Adverse Effects: Over-Replacement, Under-Replacement & Safety Risks
32:55 T4-to-T3 Conversion: Peripheral Metabolism & Clinical Implications
33:56 Drug–Drug Interactions: Absorption, Binding, and CYP Considerations
36:40 Clinical Pearls: Brand vs Generic, Lab Timing, and Optimization Tips

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#thyroiddrugtherapy #thyroidhormonepharmacology #pharmacology101 #pharmacology #pharmacologymadeeasy

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Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.