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Pharmacology

Insulin Types: Rapid, NPH, Basal for Diabetes - Pharmacology Review

Insulin pharmacology review: insulin types, onset/peak/duration, and basal–bolus dosing for Type 1 and Type 2 diabetes.

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Insulin doesn’t have to be confusing when learning how to treat Type 1 and Type 2 diabetes mellitus.  In this lecture from This is Why, Dr. Busti will explain how to quickly recognize insulin types, predict onset/peak/duration, and apply basal–bolus dosing concepts to real-world Type 1 and Type 2 diabetes care.

You’ll learn how to:
- How to identify rapid-, short-, intermediate-, and long-acting insulin for Diabetes
- The difference between basal insulin vs bolus (mealtime) insulin
- How basal–bolus regimens work (plus common pitfalls)
- Practical tips for insulin administration, timing with meals, and avoiding errors
- High-yield clinical points you’re likely to see in courses and on exams

Insulins covered (for memorization + exam success):
- Rapid-acting: insulin lispro, aspart, glulisine
- Short-acting: regular insulin
- Intermediate-acting: NPH insulin
- Long-acting / basal: insulin glargine, detemir, degludec
- Premixed options: 70/30 mixes (NPH/regular and related premixed products)

The goal = make medical education easy and clinically relevant.

Chapter Table of Contents
00:00 Introduction: Insulin Pharmacology (Type 1 vs Type 2)
01:44 Insulin Types & Formulations Overview (Rapid, Short, NPH, Basal)
03:28 Clinical Uses: Type 1, Type 2, Gestational, DKA/HHS, Hyperkalemia
05:21 Net Benefit of Insulin: Why It Works When Others Don’t
06:36 Mechanism of Action: Glucose Uptake + Metabolism (Carbs/Fat/Protein)
08:31 Normal Insulin Physiology: Basal vs Bolus (What We Mimic)
09:59 Insulin Onset/Peak/Duration Chart Explained (PK/PD Basics)
14:14 Basal Insulins (Glargine/Detemir/Degludec) & Dosing Nuances
17:00 Where Insulin Fits in Diabetes Treatment Guidelines
21:55 How to Start & Titrate Insulin (Type 1 vs Type 2 Strategies)
24:31 Timing Meals + Glucose Checks (SMBG Patterns That Guide Dosing)
30:11 Basal–Bolus Dosing Breakdown (50/50 Rule + Meal Boluses)
37:34 Common Regimens: NPH/Regular, Premix 70/30, Basal-Bolus, Pumps
43:09 Practical Tips: Mixing Insulin, NPH Cloudy, U-500 Safety, Inhaled Insulin
46:50 DKA Insulin Drip Essentials + Potassium Rules + Somogyi vs Dawn Phenomenon

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#insulin #diabetes #insulintypes #diabetespharmacology #busti

Speaker:

Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, is a licensed healthcare professional and medical educator with over 30 years of experience in clinical practice and academic teaching. He has trained and practiced as a nurse, pharmacist, and physician, bringing a uniquely comprehensive perspective to patient care and medical education.

Dr. Busti is dedicated to advancing evidence-based medicine and helping clinicians understand the underlying “why” behind clinical decisions to improve patient outcomes.


About This Channel:

This content is created by Anthony Busti, MD, PharmD, MSc, FAHA, FNLA, a board-certified physician with training at Johns Hopkins School of Medicine and University of Oxford and a medical educator for healthcare professionals and students. All material is based on current medical literature and evidence-based guidelines that align with principles of evidence-based medicine (EBM) and Evidence-Based Healthcare (EBHC).


Disclaimer:

This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

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Antidiabetic Agents Lecture Tables

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Antidiabetic Agents Lecture Tables