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In this lecture from This is Why, Dr. Busti will break down Ezetimibe (Zetia)—the classic cholesterol absorption inhibitor—and make the pharmacology easy, high-yield, and clinically relevant. You’ll learn how ezetimibe lowers LDL or LDL-C, where it fits in dyslipidemia/hyperlipidemia therapy, and how it’s commonly used as add-on therapy to statins.
You’ll learn how to:
- Mechanism of action: how the cholesterol absorption inhibitor, ezetimibe, works to lower LDL cholesterol
- Clinical use: when to use ezetimibe for LDL-C lowering (including statin add-on therapy)
- Key benefits & limitations: what ezetimibe does well—and what it does not do
- Adverse effects & counseling pearls: what to watch for in practice
The goal = make medical education easy and clinically relevant.
Chapter Table of Contents
00:00 Cholesterol Absorption Inhibitors: LDL-Lowering Overview
01:36 Ezetimibe (Zetia): Key Agent + Combination Products
02:35 Indications: HeFH/HoFH, Sitosterolemia, ASCVD Prevention
03:48 Net Benefit: Add-On to Statins + ~20% Additional LDL Lowering
04:55 Mechanism: Inhibits Intestinal Cholesterol Absorption
06:16 Lipid Effects: LDL ↓ (~20%) + TG/HDL Changes (Modest)
08:33 NPC1L1 Target: Where Ezetimibe Works in the Intestine
10:56 Indirect LDL Drop: ↓Liver Cholesterol → ↑LDL Receptors
12:12 Why It Combines Well With Statins/ACL Inhibitors
15:23 PK Pearl: Prodrug → Glucuronide + Enterohepatic Recirculation
22:26 Drug Interactions: Cyclosporine + Fibrates (Gallstones/Myopathy)
29:19 Special Population: HIV Patients + Clinical Use Findings
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#ezetimibe #cholesterolabsorptioninhibitor #zetia #ldlcholesterollowering #busti
Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
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