Factor Xa inhibitors (DOACs) made easy—fast, clear, and clinically relevant. In this lecture from This is Why, Dr. Busti will break down direct oral anticoagulants (DOACs) and how Factor Xa inhibitors work, with relevance.

‍

You’ll learn how to:
- What Factor Xa inhibitors do (mechanism of action)
- Key drugs: Apixaban (Eliquis), Rivaroxaban (Xarelto), Edoxaban (Savaysa)
- Common indications: Afib stroke prevention, DVT/PE treatment
- Major adverse effects and safety: bleeding risk, interactions, and monitoring pearls
- Reversal overview: What to know + when it matters

‍

The goal = make medical education easy and clinically relevant.

‍

Chapter Table of Contents
00:00 Intro: DOAC Factor Xa Inhibitors Overview
01:57 Which Drugs Count: Apixaban, Rivaroxaban, Edoxaban + Fondaparinux
03:11 Anticoagulant Big Picture: Xa Inhibitors vs Heparins vs Warfarin
05:23 Key Advantages vs Warfarin: Rapid Onset, No Routine INR
07:27 Reversal Landscape: Andexanet Alfa Gone → PCC Strategy
08:07 Core Indications: DVT/PE Treatment & Prophylaxis
09:27 AFib Stroke Prevention: Risk–Benefit (CHA₂DS₂-VASc, HAS-BLED)
11:23 Coagulation Cascade Refresher: Why Factor Xa Matters
13:29 Venous vs Arterial Clots: Anticoagulants vs Antiplatelets
13:58 Fondaparinux vs DOACs: Antithrombin-Dependent vs Direct Xa Inhibition
15:25 Oral vs Parenteral Xa Inhibitors: Structure & Absorption
16:34 Pharmacokinetics: Rapid Effect, Short Half-Life, Adherence
18:54 Drug Interactions: CYP3A4, P-gp, BCRP
21:20 Clinical “Do Not Use”: Mechanical Valves, Triple-Positive APS
23:35 Special Populations: Renal Dysfunction, Elderly, Low Body Weight
26:25 Bleeding Risk, Reversal, and Monitoring (CBC, CMP, LFTs)
34:40 Final Summary & Key Takeaways

‍

If this helped you, please like, subscribe to our YouTube Channel, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.

‍

Don’t forget to turn on notifications on YouTube so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!

‍

#FactorXaInhibitors #DOACs #Anticoagulation #Apixaban #drbusti

‍

Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.