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ATP Citrate Lyase (ACL) Inhibitors made simple. In this lecture from This is Why, Dr. Busti will provide you with a review of Bempedoic Acid (Nexletol), and you’ll learn how this lipid-lowering drug works, when to use it (including statin intolerance), and the key clinical pearls you need for exams and practice.
You’ll learn how to:
- What ATP citrate lyase inhibitors are and where they work in cholesterol synthesis
- Bempedoic acid mechanism of action + why it’s different from statins
- Effects on LDL cholesterol (LDL lowering drugs overview)
- Indications: hyperlipidemia, dyslipidemia, ASCVD risk reduction, statin-intolerant patients
- High-yield adverse effects, contraindications, and monitoring
- Drug interactions and counseling points you’ll actually use
The goal = make medical education easy and clinically relevant.
Chapter Table of Contents
00:00 ACL Inhibitors: What They Are + Why They Matter for LDL
02:08 Bempedoic Acid: The Only ACL Inhibitor (+ Ezetimibe Combo)
03:14 Indications: Add-On to Statins, ASCVD Prevention, HeFH
04:05 HeFH Explained: Why LDL Clearance Fails + Early ASCVD Risk
05:31 Clinical Benefit: MACE Reduction + 15–30% LDL Lowering
07:41 Mechanism Overview: Where ACL Inhibition Fits vs Statins
08:35 Bempedoic Acid Is a Prodrug: Liver Activation, Less Muscle Risk
10:01 How It Changes Lipids: LDL Targeting + Why TG/HDL Effects Differ
14:11 Cholesterol Pathway Map: ↓VLDL Output + ↑LDL Receptors
18:17 Key Safety Issue: OAT2 Competition → ↑Uric Acid & Gout Flares
19:50 Drug Interactions: Statins (Simva/Prava) + Dose Limit Rationale
21:37 Place in Therapy: Once-Daily Oral, No Major Dose Adjustments
22:37 Adverse Effects: Tendon Risk Signals, Liver/Renal Reports, Context
25:04 Monitoring: Lipid Panels + Watch for Gout/Organ Function Issues
27:10 High-Yield Recap: Indications, Mechanism, Interactions, Monitoring
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#lipidloweringdrugs LDLdrugspharmacology #BempedoicAcid #nexletol #busti
Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.
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