Dive into the coagulation cascade with this clear, clinically focused review! In this lecture from This is Why, Dr. Busti breaks down the coagulation cascade in a clear, clinically relevant way—perfect for healthcare professionals preparing for exams or patient care. Dr. Busti specifically covers the basics of hemostasis, the intrinsic and extrinsic pathways, clotting factors, vitamin K-dependent factors, thrombin functions, and how the cascade leads to thrombus formation (including key differences between venous and arterial thrombi). Learn "why" understanding normal physiology is essential for recognizing pathology and choosing the right interventions to prevent bleeding or thrombosis.

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Key topics include:

- Normal clotting factor synthesis & activation

- Role of vitamin K and the coagulation cascade

- Thrombin's multiple functions in clot formation, stabilization, and fibrinolysis

- Clinical relevance: What happens when the balance is disrupted?

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Whether you're studying or simply want to understand the "why" behind anticoagulation and hemostasis management, this physiology review makes complex concepts easy and applicable.

Chapters

00:00 Coagulation cascade basics: why clots matter clinically
01:33 Arterial vs venous thrombus: the 2 clot types to know
01:43 Red vs white thrombus: what’s inside the clot
02:29 Vessel injury triggers: trauma vs plaque rupture
04:17 Arterial vs venous thrombus table: key differences
05:03 What starts clots: plaque rupture vs stasis (DVT and AFib)
07:05 Composition drives treatment: antiplatelets vs anticoagulants
08:31 Occlusion vs embolization: how DVT becomes PE
10:57 Coagulation cascade and platelets: how the systems connect
11:36 Thrombin’s central role and why drugs target it
12:39 Vitamin K–dependent factors and the vitamin K cycle
14:12 Warfarin mechanism: blocking vitamin K recycling
17:21 Pathways converge at Xa to thrombin to fibrin
28:13 Thrombophilias, bleeding disorders, and anticoagulant drug classes

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#CoagulationCascade #Hemostasis #BloodClottingCascade #PhysiologyMadeEasy #drbusti

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Disclaimer:

This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.